TRANSCRIPTOMICS-INFORMED PHARMACOLOGY IDENTIFIES EPIGENETIC AND CELL CYCLE REGULATORS THAT ENHANCE AAV PRODUCTION

Transcriptomics-informed pharmacology identifies epigenetic and cell cycle regulators that enhance AAV production

Recombinant adeno-associated virus (rAAV) is a widely used viral vector for gene therapy.However, these vectors have limited availability due to manufacturing challenges with productivity and quality.These challenges can be addressed by better understanding the mechanisms that influence cellular responses during rAAV production.In this study, we ai

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Net diversification rates of the woody plant genus Petalidium (Acanthaceae) are highest in the ancient and arid Namib Desert

At present, tropical arid biomes house less woody plant species diversity than tropical moist biomes, which could be due to lower rates of evolutionary diversification in the recent or distant past.Here, we study the evolutionary diversification of Petalidium (Acanthaceae), a genus of 36 species of woody shrubs found in the Namib Desert of southwes

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Piloting a mental health training programme for community health workers in South Africa: an exploration of changes in knowledge, confidence and attitudes

Abstract Background There is a shortage of trained mental health workers in spite of the significant contribution of psychiatric disorders to the global disease burden.Task shifting, through the delegation of health care tasks to less specialised health workers such as community health workers (CHWs), is a promising approach to address the human re

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